Apremilast

Status	Pipeline
Therapeutic cat.	Musculo-skeletal
Polymorphic form	Form B
CAS No.	608141-41-9
EU DMF readiness
CANADIAN??DMF
US DMF readiness

Drug description

Apremilast (Otezla) is used to treat plaque psoriasis, psoriatic arthritis, and Beh?et's disease in specific patients. Apremilast tablets help improve plaque psoriasis for clearer skin and reduce inflammation and symptoms such as pain, redness, and swelling in psoriatic arthritis and Behcet's disease. Apremilast is a PDE4 inhibitor that works by increasing the level of cAMP (cyclic adenosine monophosphate), a messenger involved in cell signaling in our bodies. Apremilast is not a biologic agent. Apremilast, under the brand name Otezla, received FDA approval on March 21, 2014, for psoriatic arthritis. Since then, it has also been FDA-approved to treat types of plaque psoriasis and Behcet’s disease in specific patients. It is not available as a generic medicine.

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