Ceftriaxone sodium showed a similar antibacterial spectrum to ceftaxime sodium. It has a powerful effect on e. coli, pneumobacillus, indole-positive proteus, influenzae bacillus, Charley bacillus, meningococci and gonococci. Moderate sensitivity to pneumococcus, streptococcus and staphylococcus aureus; It has certain effect on pseudomonas aeruginosa, enterococcus, methicillin-resistant staphylococcus and most fragile bacteroides.

Combined with aminoglycoside drugs, it has synergistic antibacterial effect, but may aggravate renal damage at the same time. Adverse events that may lead to fatal outcomes when combined with calcium or calcium-containing products; This product may affect the ethanol metabolism, causes the blood acetylaldehyde concentration to rise, appears the disulfide kind reaction; Benzodiazepine does not affect the elimination of this product. It was found that chloramphenicol combined with ceftriaxone could produce antagonistic effect in vitro.