Product Name: Methotrexate

CAS No.: 59-05-2

Chemical Name:

L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methyl-amino]benzoyl]-;

L-(+)-N-[p-[[2,4-diamino-6-pteridinyl)methylamino]benzoyl] glutamic acid;

(S)-2-(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzamido)pentanedioic acid

Standard/Specification: CP/USP/BP/EP

Appearance: a yellow to orange, crystalline powder

Assay: 98%~102%

Water: not more than 12%

Storage: preserve in tight, light-resistant containers.

Methotrexate is a drug with a wide range of clinical applications. Here's a look at how it works: # # # # mechanism of action - As a folate antagonist, metotrexate has a high affinity with the dihydrofolate reductase enzyme, which when combined prevents dihydrofolates from being reduced to tetrahydrofolate. Tetrahydrofolate is an important coenzyme within the cell that is involved in the synthesis of purine nucleotide and pyridine nucleotide. Methotrexate inhibits the synthesis of DNA, RNA and opal by inhibiting the production of tetrahydrofolate, and ultimately inhibits cell proliferation and division.