HP-SCX is a silica based mixed-mode strong cation exchange phase. The phase has a mixed chemical structure of sulfonic acid and phenyl group. The mixed mode of strong cation-exchange and hydrophobicity offers unique selectivity and high resolution separation for cationic/basic and nitrogen containing compounds as well as desirable retention for a variety of weak cationic and neutral organic compounds. The uniform polymeric bonding of HP-SCX enhances its stability under various separation conditions.

HP-SCX has expanded its applications from the traditional SCX separation of cationic and nitrogen containing compounds to weak cationic and neutral organic molecules. Examples include separation of analytes of amines and polyamines, such as alkaloids, peptides, codeine, and cough and cold ingredients.