Sesamin is the most prominent lignan in sesame seeds. Sesamin is catered to be a nutritional supplement that confers antioxidant and antiinflammatory effects. Besides sesamin, the sesame seeds also have other lignans, including sesamolin, sesaminol and sesamol etc.

1. Antioxidant: As assessed by temporal ESR (a way to measure antioxidant effects in vivo using an injection of TEMPOL) 250 mg/kg Sesamin with 10 mg/kg vitamin E appears to increase reducing capacity of the liver (indicative of antioxidant effects) by 10-15% relative to control which is then normalized within one day following oral ingestion. (Anal Sci 2013, 29, 89.)
2. Skin cancer: Sesamin appears to augment the skin accumulation of γ-tocotrienol, and secondary to that increases its protective effects (J Nutr Sci Vitaminol 2008, 54, 117.). In short, Sesamin appears to augment the actions of all vitamin E vitamers simply because it allows more vitamin E to bioaccumulate in your body and exert their effects.