Small swift biotechs to lead a ‘golden age’ of next generation therapies such as CAR-T, combination therapies, innate immune system approaches, and newer check-point inhibitors.

Biotechs such as Wuxi Apptech lead a ‘golden age’ of next generation therapies.

WuXi AppTec published a new report on the future of immunotherapy treatments, and identified smaller, nimble biotechs and early-stage companies as the single biggest factor behind the next generation of approaches in development. The report concludes that the next 5 years will be the most promising in the fight against cancer with immunotherapies – such as CAR-T and moderating T-Cell approaches, and innate immunity therapies – delivering far better patient outcomes.

During the last 5 years, the industry has rapidly advanced its understanding of the body’s immune response and genetic markers. As a result, combination therapies (chemotherapies will continue to play an important role) are forecast to become an increasingly standardized treatment with pharma keen to invest. These newer options are bringing in transformative remission rates, and check-point inhibitors have already been seen to elicit long-term cures in patients, with success rates at two-to-three times more than standard chemotherapy approaches.

The report predicts that during the next 10 years, we will see significantly greater breakthroughs as the industry’s understanding of the immune system improves. There are currently more than 130 biotechs working on new therapies – in addition to 20 big pharmas – and it is believed the smaller companies are more aggressively bringing newer innovations to market. In the long run, pharma will undoubtedly absorb the most promising players in an effort to become leaders in combination therapy approaches, which many argue will deliver the best outcomes.

"The current investor frenzy is comparable to that of the genomics industry at the turn of the century," said Hui Cai, VP of Corporate Alliances and Head of Communications at WuXi AppTec. "The experts we speak with argue that a more complete understanding of the genome and promise of clinical data of these transformative modalities will create a golden age for cancer therapy emerge over the next few years."

The report does, however, identify a number of immediate challenges; for example, CAR-T, although demonstrating good efficacy in blood cancers, has yet to show enough efficacy in solid tumors. Another challenge is how far towards cures for all patients we can get, particularly for patients with late stage metastatic cancer.

The report concludes that immunotherapies are driving cancer from treatment plans that simply extend life or improve experience to more effective cures. The cost of newer therapies is also drawing attention; however, this is a positive influence on companies to make great improvement, not just small changes for patients.