Severe vitamin D deficiency is associated with an increased risk for renal hyperfiltration (RHF) in relatively healthy adults, according to a study published in the December issue of The American Journal of Clinical Nutrition.

Jong Hyun Jhee, from the Inha University College of Medicine in Incheon, South Korea, and colleagues analyzed data from the Korean National Health and Nutrition Examination Survey study (2008 to 2015) to evaluate the association between RHF and vitamin D status among 33,210 participants with normal renal function. Severe vitamin D deficiency was defined as serum 25-hydroxyvitamin D concentration <10 ng/mL.

The researchers found that estimated glomerular filtration rate was negatively associated with serum 25-hydroxyvitamin D concentrations in multivariable linear regression analysis. Overall, 4.9 percent of individuals (1,637) were classified as having RHF. The prevalence of RHF was significantly higher in the severe vitamin D deficiency group than in the sufficient group (5.8 versus 5 percent). In a multivariable logistic regression model, severe vitamin D deficiency was a significant risk factor for RHF (odds ratio, 2.41).

"These findings suggest that early screening and management of severe vitamin D deficiency is beneficial for protecting renal function in a relatively healthy population," the authors write.

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