Adults with young-onset type 2 diabetes (T2D; onset before age 40 years) have an increased hospitalization risk across their life span compared with those with usual-onset T2D, according to a study published online Jan. 15 in the Annals of Internal Medicine.

Calvin Ke, M.D., from the Chinese University of Hong Kong, S.A.R., China, and colleagues conducted a prospective cohort study involving adults aged 20 to 75 years in population-based (2002 to 2014; 422,908 adults) and registry-based (2000 to 2014; 20,886 adults) T2D cohorts to determine hospitalization rates.

The researchers found that the highest hospitalization rates by attained age were seen for patients with young-onset T2D (YOD). Mental illness accounted for 36.8 percent of YOD bed-days before age 40 years in the registry cohort. Compared with usual-onset T2D (onset ≥40 years), hospitalization was increased in YOD (adjusted rate ratios: 1.8 for all-cause, 6.7 for renal, 3.7 for diabetes, 2.1 for cardiovascular, and 1.7 for infection). Intensified risk factor control in YOD was correlated with a reduction of one-third in cumulative bed-days from onset to age 75 years (from 97 to 65 bed-days).

"This costly burden is an urgent call for policymakers, payers, patients, and health care providers to take action and address this unmet need," the authors write. "An integrated system is needed to identify patients with YOD for comprehensive assessment of physical and psychological health."

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