Ion exchange chromatography(IEC)is a very effective method for the separation and purification of biomolecule. The method mainly relies on the interaction between positive and negative charges, and uses the charge properties and differences of different biological molecules under specific conditions to separate them. It has the characteristics of high load, good resolution, controllable condition and easy scale-up. It has been widely used in medicine, chemical industry, metallurgy, food and other fields.

IEC resin is composed of three parts: (1)Cross-linked agarose matrix, that has the characteristics of porous, hydrophilic and good chemical stability; through the modification to traditional agarose molecules, it has stronger mechanical properties, which is called high rigid agarose, namely Diamond matrix; (2)Functional groups fixed to the matrix, which are electrically charged groups, determine the properties of the IEC resin; (3)An ion (called an equilibrium ion) that has an opposite charge to the functional group and can be reversibly bound to the functional group.

Diamond Q Mustang is a strong anion exchange resin formed by coupling quaternary ammonium groups to fine-grained high-rigidity agarose microspheres. It has a higher resolution than Diamond Q and is suitable for polished or intermediate purification in the chromatography step.