MaXtar® PlasmidCap HR is a thiophilic aromatic adsorption chromatography resin. Thiophilic affinity chromatography works by using the interaction between electron donors and acceptors to separate and purify target molecules. This interaction can be strengthened in a high-salt environment and weakened in a low-salt environment. MaXtar® PlasmidCap HR can selectively bind to closed-loop supercoiled plasmid DNA but not to open-loop plasmid DNA. Therefore, it can be used to prepare high-quality plasmid DNA.

Unlike PlasmidCap Chromstar HP chromatography resin, MaXtar® PlasmidCap HR conjugates the sulfur-containing compound 2-mercaptopyridine to a new highly rigid matrix, which provides better pressure-flow performance for large-scale separation and purification of plasmid DNA, bringing added flexibility in process design and improved productivity. Also, finer particle sizes can provide better resolution.

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