TANGENTIAL FLOW FILTRATION

BRIEF INTRODUCTION

AITESEN LDS series Tangential Flow Filtration is mainly applied in the research of tangential flow ultrafiltration technology for micro & nano drugs and biological products, providing excellent technical services and solutions.

The equipment can be used for process research experiments on small-scale samples, as well as for large-scale process validation experiments. The equipment is equipped with a touch screen operating system and software programs for automatic data recording, supporting data tracing and export. The process is reliable and suitable for programmatic amplification. The components comply with pharmaceutical industry standards, they are safe and reliable.

TFF:

Tangential Flow Filtration (TFF) is currently a widely used membrane separation technology. The sample is driven by pressure, and the content is separated by membrane filtration according to different molecular sizes, achieving the goals of removing heat, replacing the solution environment, purification ,and concentration.

PRINCIPLE：

The implementation process of TFF is fundamentally different from dead end filtration. As the filtrate passes through the membrane components, the sample solution continuously passes through the membrane surface in a vertical direction.

MEMBRANE PARTS：

用于切向流過濾的膜組件通常是膜組件或中空纖維柱，兩者都有多種型號，以滿足不同的使用需求。膜材料的種類和孔徑、溶液循環(huán)流速、膜兩側(cè)壓力、樣品溫度、膜兩側(cè)工藝、樣品溫度、工藝時(shí)間等參數(shù)對于切向流過濾非常重要。他們決定了最終的工藝效果，以及大規(guī)模生產(chǎn)的可行性和具體計(jì)劃。實(shí)驗(yàn)室規(guī)模的切向流過濾設(shè)備致力于獲得可行的工藝方案和可靠的工藝參數(shù)，確定適合大規(guī)模實(shí)驗(yàn)和生產(chǎn)的工藝參數(shù)，為設(shè)備或系統(tǒng)選型提供有效依據(jù)。

T FF流程圖

應(yīng)用領(lǐng)域

核酸藥物和疫苗

mRNA-LNP、siRNA、聚合物納米顆粒等

化療脂質(zhì)體

鹽酸阿霉素脂質(zhì)體

鹽酸伊立替康脂質(zhì)體

柔紅霉素脂質(zhì)體

復(fù)合脂質(zhì)體等

解決方案系統(tǒng)位移

替代緩沖溶液

納米藥物溶液的外置水相置換

細(xì)胞產(chǎn)物分離純化

發(fā)酵液細(xì)胞的收集和純化

澄清過程

質(zhì)粒、單克隆抗體、蛋白純化

質(zhì)粒、mRNA、siRNA等

（二）LDS-L2TANGENTIAL FLOW FILTRATION

TECHNICAL PARAMETER：

EQUIPMENT FEATURES：

Automated Ultrafiltration System

It can achieve unmanned automated TFF process and execute complex TFF processes through integrated monitoring of user specified settings within the integrated PLC software platform.

Professional Operating System

Special software with simple operating logic, real-time tracking, real-time data analysis, and compliance with FDA 21 CFR PART 11 data audit tracking.

Drug R&D Orientation

The equipment design is based on the process requirements and regulatory specifications for drug development and production, and can be used for the implementation of processes such as purification, solvent removal, and concentration of liposome, lipid nanoparticles, and other formulations.