TANGENTIAL FLOW FILTRATION

BRIEF INTRODUCTION

AITESEN LDS series Tangential Flow Filtration is mainly applied in the research of tangential flow ultrafiltration technology for micro & nano drugs and biological products, providing excellent technical services and solutions.

The equipment can be used for process research experiments on small-scale samples, as well as for large-scale process validation experiments. The equipment is equipped with a touch screen operating system and software programs for automatic data recording, supporting data tracing and export. The process is reliable and suitable for programmatic amplification. The components comply with pharmaceutical industry standards, they are safe and reliable.

TFF:

Tangential Flow Filtration (TFF) is currently a widely used membrane separation technology. The sample is driven by pressure, and the content is separated by membrane filtration according to different molecular sizes, achieving the goals of removing heat, replacing the solution environment, purification ,and concentration.

PRINCIPLE：

The implementation process of TFF is fundamentally different from dead end filtration. As the filtrate passes through the membrane components, the sample solution continuously passes through the membrane surface in a vertical direction.

MEMBRANE PARTS：

用于切向流過濾的膜組件通常是膜組件或中空纖維柱，兩者都有多種型號，以滿足不同的使用需求。膜材料的種類和孔徑、溶液循環(huán)流速、膜兩側(cè)壓力、樣品溫度、膜兩側(cè)工藝、樣品溫度、工藝時間等參數(shù)對于切向流過濾非常重要。他們決定了最終的工藝效果，以及大規(guī)模生產(chǎn)的可行性和具體計劃。實驗室規(guī)模的切向流過濾設(shè)備致力于獲得可行的工藝方案和可靠的工藝參數(shù)，確定適合大規(guī)模實驗和生產(chǎn)的工藝參數(shù)，為設(shè)備或系統(tǒng)選型提供有效依據(jù)。

T FF流程圖

應(yīng)用領(lǐng)域

核酸藥物和疫苗

mRNA-LNP、siRNA、聚合物納米顆粒等

化療脂質(zhì)體

鹽酸阿霉素脂質(zhì)體

鹽酸伊立替康脂質(zhì)體

柔紅霉素脂質(zhì)體

復(fù)合脂質(zhì)體等

解決方案系統(tǒng)位移

替代緩沖溶液

納米藥物溶液的外置水相置換

細(xì)胞產(chǎn)物分離純化

發(fā)酵液細(xì)胞的收集和純化

澄清過程

質(zhì)粒、單克隆抗體、蛋白純化

質(zhì)粒、mRNA、siRNA等

LDS-L1 切向流過濾

技術(shù)參數(shù)S：

設(shè)備特點：

自動 Ultrafiltration S系統(tǒng)

它可以實現(xiàn)無人化的自動化TFF過程，并通過在集成PLC軟件平臺內(nèi)對用戶指定設(shè)置進(jìn)行集成監(jiān)控來執(zhí)行復(fù)雜的TFF過程。

專業(yè) Operating System

具有簡單操作邏輯、實時跟蹤、實時數(shù)據(jù)分析以及符合 FDA 21 CFR PART 11 數(shù)據(jù)審計跟蹤的專用軟件。

藥物研發(fā)

設(shè)備設(shè)計基于藥物研發(fā)生產(chǎn)的工藝要求和監(jiān)管規(guī)范，可用于脂質(zhì)體、脂質(zhì)納米顆粒等制劑的純化、溶劑去除、濃縮等工藝的實施。